There is no right answer to this. The nutrient levels in the system dictate how you adjust the schedules and every system is different.
Generally, newer systems have higher nutrient loads and a harder time removing them. On these, running the skimmer 24/7 and the refugium up to 18-20hrs a day is not uncommon.
As systems mature and the coral biomass goes up it's ability to uptake nutrients go up. But then there's different types of systems...
FOWLR would stay at the max.
Softy/LPS would lean towards the max as well.
Mixed reef. This is where tuning will become more of a factor.
SPS dominant. Tuning is now important.
The faster coral grows the more it can take up nutrients. And it goes up exponentially the more mass there is. Some people will actually end up having to dose NO3 & PO4 just to keep detectable levels after cutting the skimmer back to 12hrs and shutting down the fuge entirely. Again every system is different.